- Amoebic Encephalitis Caused by Balamuthia mandrillaris
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Su Jung Kum, Hye Won Lee, Hye Ra Jung, Misun Choe, Sang Pyo Kim
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J Pathol Transl Med. 2019;53(5):327-331. Published online May 24, 2019
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DOI: https://doi.org/10.4132/jptm.2019.05.14
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- We present the case of a 71-year-old man who was diagnosed with amoebic encephalitis caused by Balamuthia mandrillaris. He had rheumatic arthritis for 30 years and had undergone continuous treatment with immunosuppressants. First, he complained of partial spasm from the left thigh to the left upper limb. Magnetic resonance imaging revealed multifocal enhancing nodules in the cortical and subcortical area of both cerebral hemispheres, which were suggestive of brain metastases. However, the patient developed fever with stuporous mentality and an open biopsy was performed immediately. Microscopically, numerous amoebic trophozoites, measuring 20 to 25 µm in size, with nuclei containing one to four nucleoli and some scattered cysts having a double-layered wall were noted in the background of hemorrhagic necrosis. Based on the microscopic findings, amoebic encephalitis caused by Balamuthia mandrillaris was diagnosed. The patient died on the 10th day after being admitted at the hospital. The diagnosis of amoebic encephalitis in the early stage is difficult for clinicians. Moreover, most cases undergo rapid deterioration, resulting in fatal consequences. In this report, we present the first case of B. mandrillaris amoebic encephalitis with fatal progression in a Korean patient.
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- Molecular identification, phylogenetic analysis and histopathological study of pathogenic free-living amoebae isolated from discus fish (Symphysodon aequifasciatus) in Iran: 2020–2022
Hooman Rahmati-Holasoo, Maryam Niyyati, Marziye Fatemi, Fatemeh Mahdavi Abhari, Sara Shokrpoor, Alireza Nassiri, Amin Marandi BMC Veterinary Research.2024;[Epub] CrossRef - Encephalomyelomeningitis Caused by Balamuthia mandrillaris: A Case Report and Literature Review
XueMei Fan, TianWen Chen, Hui Yang, Yue Gao, Yan Chen Infection and Drug Resistance.2023; Volume 16: 727. CrossRef - Diagnosing Balamuthia mandrillaris amebic meningoencephalitis in a 64-year-old woman from the Southwest of China
Suhua Yao, Xiaoting Chen, Lian Qian, Shizheng Sun, Chunjing Zhao, Zongkai Bai, Zhaofang Chen, Youcong Wu Parasites, Hosts and Diseases.2023; 61(2): 183. CrossRef - Diagnosis of Balamuthia mandrillaris Encephalitis by Thymine–Adenine Cloning Using Universal Eukaryotic Primers
Ju Yeong Kim, Myung-Hee Yi, Myungjun Kim, Joon-Sup Yeom, Hyun Dong Yoo, Seong Min Kim, Tai-Soon Yong Annals of Laboratory Medicine.2022; 42(2): 196. CrossRef - Facial Balamuthia mandrillaris infection with neurological involvement in an immunocompetent child
Zhen Zhang, Jianying Liang, Ruoqu Wei, Xiaobo Feng, Lei Wang, Liuhui Wang, Piaoping Zhao, Hong Yu, Yan Gu, Zhirong Yao The Lancet Infectious Diseases.2022; 22(3): e93. CrossRef - Subacute Balamuthia mandrillaris encephalitis in an immunocompetent patient diagnosed by next-generation sequencing
Changbo Xu, Xiaoyan Wu, Miaoqin Tan, Dongmei Wang, Shengnan Wang, Yongming Wu Journal of International Medical Research.2022; 50(5): 030006052210932. CrossRef - Distribution and Current State of Molecular Genetic Characterization in Pathogenic Free-Living Amoebae
Alejandro Otero-Ruiz, Leobardo Daniel Gonzalez-Zuñiga, Libia Zulema Rodriguez-Anaya, Luis Fernando Lares-Jiménez, Jose Reyes Gonzalez-Galaviz, Fernando Lares-Villa Pathogens.2022; 11(10): 1199. CrossRef - Fulminant Disseminating Fatal Granulomatous Amebic Encephalitis: The First Case Report in an Immunocompetent Patient in South Korea
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Ryogo Aoki, Toshimasa Sakakima, Asuka Ohashi, Riyoko Niwa, Masashi Matsuyama, Fumimasa Etori, Naoki Watanabe, Kenji Yagita, Takuji Tanaka Clinical Case Reports.2020; 8(9): 1728. CrossRef -
Balamuthia mandrillaris
infection in China: a retrospective report of 28 cases
Lei Wang, Wenjing Cheng, Bing Li, Zhe Jian, Xianlong Qi, Dongjie Sun, Jian Gao, Xuetao Lu, Yi Yang, Kun Lin, Chuanlong Lu, Jiaxi Chen, Chunying Li, Gang Wang, Tianwen Gao Emerging Microbes & Infections.2020; 9(1): 2348. CrossRef - Methotrexate/nonsteroidal anti-inflammatory drugs/steroids
Reactions Weekly.2019; 1775(1): 307. CrossRef - Identification of plicamycin, TG02, panobinostat, lestaurtinib, and GDC-0084 as promising compounds for the treatment of central nervous system infections caused by the free-living amebae Naegleria, Acanthamoeba and Balamuthia
Monica M. Kangussu-Marcolino, Gretchen M. Ehrenkaufer, Emily Chen, Anjan Debnath, Upinder Singh International Journal for Parasitology: Drugs and Drug Resistance.2019; 11: 80. CrossRef
- Bile Granuloma Mimicking Peritoneal Seeding: A Case Report
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Hasong Jeong, Hye Won Lee, Hye Ra Jung, Ilseon Hwang, Sun Young Kwon, Yu Na Kang, Sang Pyo Kim, Misun Choe
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J Pathol Transl Med. 2018;52(5):339-343. Published online July 16, 2018
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DOI: https://doi.org/10.4132/jptm.2018.06.02
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- Laparoscopic cholecystectomy is a widely used treatment method for most cholelithiasis and is a relatively safe procedure. Foreign body granulomatous reaction to bile or gallstone spillage during laparoscopic cholecystectomy has rarely been reported. We report a case of bile granuloma after laparoscopic cholecystectomy, which mimicked peritoneal seeding. A 59-year-old Korean man presented with right upper quadrant pain. He underwent laparoscopic cholecystectomy for acute cholecystitis with cholelithiasis. Pathologic examination revealed an incidental adenocarcinoma invading the lamina propria with acute cholecystitis and cholelithiasis. After 3 months, follow-up abdominal computed tomography revealed a subhepatic nodule, which showed hypermetabolism on positron emission tomography–computed tomography. Suspecting localized peritoneal seeding, wedge resection of the liver, wedge resection of the transverse colon, and omentectomy were performed. Pathologic examination of the resected specimens revealed multiple bile granulomas. Awareness of bile granuloma mimicking malignancy is noteworthy for patient management to reduce unnecessary procedure during postoperative surveillance.
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- A mimic of peritoneal metastatic disease, multifocal intraabdominal foreign body granulomas secondary to feculent peritonitis
Damien Gibson, Christo Joseph, Diarmid P. Foulis, Christophe R. Berney ANZ Journal of Surgery.2024; 94(4): 763. CrossRef - Practices and Attitudes of Surgeons With Regard to Spilled Gallstones During Laparoscopic Cholecystectomy: A Cross-Sectional Study From Saudi Arabia
Mohammed Alfehaid, Moath Aljohani, Sajad A Salati , Shoug Alaodah, Wejdan Alresheedi, Raghad Almarshud Cureus.2024;[Epub] CrossRef - Spilled gallstone mimicking intra-abdominal seeding of gallbladder adenocarcinoma: A case report
Cheng-Ken Huang, Ruey-Hwa Lu, Chien-Cheng Chen, Po-Chun Chen, Wen-Chang Hsu, Meng-Jui Tsai, Chin-Tsung Ting World Journal of Gastrointestinal Surgery.2024; 16(2): 622. CrossRef - Biliary Granulomatous Peritoneal Reaction as Consequence of Cholecystectomy: Case Report and Literature Review
Giuseppe Tarantino, Denise Menghini, Maria Eva Argenziano, Miriam Palmieri, Alessandra Mandolesi, Enrico Dalla Bona, Antonio Benedetti, Mario Guerrieri, Maria Giovanna Danieli SN Comprehensive Clinical Medicine.2023;[Epub] CrossRef - Foreign body reaction mimicking local recurrence from polyactide adhesion barrier film after laparoscopic colorectal cancer surgery
Tien-Chan Hsieh, Chao-Wen Hsu Medicine.2022; 101(5): e28692. CrossRef - Spilled gallstones after laparoscopic cholecystectomy: a systematic review
Sajad Ahmad Salati, Mohammed Alfehaid, Saleh Alsuwaydani, Lamees AlSulaim Polish Journal of Surgery.2022; 94(4): 1. CrossRef - Foreign body granulomas mimic peritoneal dissemination caused by incarcerated femoral hernia perforation: A case report
Shinpei Ogino, Tatsuya Matsumoto, Yosuke Kamada, Noriaki Koizumi, Hiroshi Fujiki, Kenji Nakamura, Takeshi Yamano, Chouhei Sakakura World Journal of Clinical Oncology.2021; 12(11): 1083. CrossRef
- IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma
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Ji Young Park, Misun Choe, Yuna Kang, Sang Sook Lee
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Korean J Pathol. 2014;48(2):108-116. Published online April 28, 2014
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DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.2.108
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- Background
Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes. MethodsWe studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed. ResultsTwenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival. ConclusionsIMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.
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Citations
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- IMP3 Immunohistochemical Expression Is Related with Progression and Metastases in Xenografted and Cutaneous Melanomas
Natividad Martin-Morales, Miguel Padial-Molina, Isabel Tovar, Virginea De Araujo Farias, Pedro Hernández-Cortés, Esperanza Ramirez-Moreno, Mercedes Caba-Molina, Justin Davis, Alejandro Carrero Castaño, Jose Mariano Ruiz de Almodovar, Pablo Galindo-Moreno, Pathobiology.2024; 91(2): 132. CrossRef - circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma
Yuenan Liu, Kailei Chen, Yi Shou, Sen Li, Jun Wang, Qingyang Zhang, Ziwei Huang, Jiaju Xu, Mingfeng Li, Di Liu, Huageng Liang, Hongmei Yang, Xiaoping Zhang Clinical and Translational Medicine.2023;[Epub] CrossRef - Prognostic value of insulin‑like growth factor 2 mRNA‑binding protein 3 and vascular endothelial growth factor‑A in patients with primary non‑small‑cell lung cancer
Jiannan Liu, Ying Liu, Wenjing Gong, Xiangshuo Kong, Congcong Wang, Shuhua Wang, Aina Liu Oncology Letters.2019;[Epub] CrossRef - Epithelial‑mesenchymal transition in colorectal carcinoma cells is mediated by DEK/IMP3
Shuping You, Yun Guan, Weihong Li Molecular Medicine Reports.2017;[Epub] CrossRef
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